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Barshop Institute for Longevity and Aging Studies

Clinical Trial Participation

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Current Clinical Trials in Aging Research

 

The University of Texas Health Science Center and the San Antonio Geriatric Research, Education and Clinical Center (GRECC) at the Audie L. Murphy Memorial VA Hospital partner to initiate clinical research trials to further the medical knowledge of specific treatments and preventions of various age-related diseases. By participating in clinical trials, you can help make a difference in the care and treatment of future patients.

Click on a study below to view more information.

You can also find more clinical trials at UTHSCSA Find-A-Study.


(Funded by a grant from the National Institute of Health Older American Independent Center: Stress-Busting Program and Qol, Biomarkers of Immunity/Stress and Cellular Aging)
Currently Recruiting

The purpose of this study is to explore the differences in quality of life, inflammation, stress, telomere length, and mucosal immune function of Hispanic and non-Hispanic caregivers of persons with Alzheimer's disease and related dementias (ADRD). The caregivers will complete the Stress-Busting Program for Family Caregivers in the language of their choice (English or Spanish).

Contact: 210-450-0020        

Location: Multiple Locations


(Funded by a grant from the National Institute of Health Older American Independent Center)
Currently Recruiting

The purpose of the study is to find out if metformin treatment prevents or reduces frailty in older adults who are pre-diabetic. Frailty is a geriatric syndrome which leads people to falls, become disabled, require nursing home placement, and have increased risk for death.

Contact: 210-450-0020

Location: 7th Floor STVHCS Audie L. Murphy VA Hospital in the Bartter Research Unit (BRU)


Effect of mTOR Inhibition and Other Metabolism Modulating Intervention on the Elderly: Immune, Cognitive, and Functional Consequences
(Funded by a grant from the National Institute of Health Older American Independent Center)
Currently Recruiting

The purpose of this study is to evaluate the effects of Rapamycin and Acarbose on muscle strength, cognition, immune function and physical performance in adults Age 70-95 (Non-smokers in general good health, without diabetes, without recent history of heart attack, or not taking blood thinners).

Contact: 210-450-0020      

Location: 7th Floor STVHCS Audie L. Murphy VA Hospital in the Bartter Research Unit (BRU)


 
(Funded by a grant from the National Institute of Health Older American Independent Center)
Closed to Recruitment

Subjects previously diagnosed with or without Mild Cognitive Impairment (MCI) by the Texas Alzheimer's Research Study (TARC).  Study involve 5 visits and intermittent phone contact by study coordinator.  Participants are randomized to Vitamin B3 /Placebo and follow incremental dose increases weeks 1-3 then wk. 4-10 are on standardized dose till study completion.

 

The Role of TLR4 on Lipid-Induced Insulin Resistance in Human Subjects

(Funded by a grant from the National Institutes of Health/
National Institute of Diabetes and Digestive and Kidney Diseases)
Closed to Recruitment

Dr. Musi’s research interest is studying the causes of Type 2 diabetes, a disease that affects more than 27 million Americans, based on the 2014 National Diabetes Statistics Report. Another 86 million have pre-diabetes and are at risk for developing this disease. His current research on insulin resistance centers on understanding the causes of diabetes at the molecular level and identifying ways to reverse the molecular abnormalities seen in Type 2 diabetes patients.

(AIM 1) The Role of TLR4 on Lipid-Induced Insulin Resistance

This study will use an investigational medication to determine whether it can prevent inflammation and insulin resistance in lean and healthy subjects with normal glucose tolerance. Conducted at the South Texas Audie L. Murphy VA Hospital, the study is currently enrolling from all ethnic groups, veterans and non-veterans, and non-smokers between ages 18 and 65 without family history of diabetes.

(AIM 2) The Effect of TLR4 Inhibition in Obese and Type 2 Diabetic Subjects

Similarly, this study uses the same investigational medication to determine whether it can prevent inflammation and insulin resistance in those who are Type 2 diabetic subjects or obese with impaired glucose tolerance, compared to lean, normal glucose-tolerant subjects. Also conducted at the VA Hospital, the study is enrolling subjects taking sulfonylureas or metformin (not insulin-dependent), who are non-smokers, and between the ages of 18 and 65.

(Funded by a grant from the American Diabetes Association)
Closed to Recruitment

(AIM 1) This outpatient study will evaluate how a probiotic (a type of good bacteria) and food composition affect the metabolism. Recent research suggests that diets that have a high fat content increase the level of a substance called ''endotoxin'' in the blood and also suggests that endotoxins might affect the way the body metabolizes (burns) sugars. We will study healthy people without diabetes who are lean.  Conducted at the South Texas Audie L. Murphy VA Hospital, the study is currently enrolling from all ethnic groups, veterans and non-veterans, and non-smokers between ages 18 and 65 without family history of diabetes.

(AIM 2) This outpatient study will evaluate how a probiotic (a type of good bacteria) affects the metabolism. Recent research suggests that people who are overweight or who have Type 2 diabetes have an elevation in the level of a substance called ''endotoxin'' in the blood, and this study will examine if lowering the level of endotoxins will improve the way the body metabolizes (burns) sugars. We will also study healthy people without diabetes who are lean (see Aim 1). Volunteers will be non-smokers between the ages of 18 and 65. Also conducted at VA Hospital.

(Funded by Texas Alzheimer's Research Consortium)
Closed to Recruitment

We want to learn more about the causes and treatment of Alzheimer's and related disorders. We are participating in the Texas Alzheimer's Research Study (TARC). TARC is a non-profit state funded institution that promotes Alzheimer's research.

Cognitive and Functional Connectivity Effects of Methylene Blue in Healthy Aging, Mild Cognitive Impairment and Alzheimer's Disease

(Funded by a grant from the National Institute of Health Older American Independent Center)
Closed to Recruitment

We will be studying both healthy, MCI (mildly cognitively impaired males and females) between the ages of 45-89, and subjects diagnosed with Alzheimer's disease between the ages of 65-79 and will be looking at the effects of Methylene Blue on memory and cognition.


 
 
   
 
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The Sam and Ann Barshop Institute for Longevity and Aging Studies

15355 Lambda Drive
San Antonio, Texas  78245
P: 210-562-6140 F: 210-562-6110

Contact: barshopinstitute@uthscsa.edu
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