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Barshop Institute for Longevity and Aging Studies

Linda M. McManus, Ph.D.


Linda M. McManus, Ph.D.

Director, Office of Postdoctoral Affairs
Distinguished Teaching Professor of Pathology
Department of Pathology
University of Texas Health Science Center at San Antonio
Phone: 210-567-4071


Parenchymal tissue injury initiates a rapid cascade of tightly-regulated cellular events designed to repair and/or regenerate the damaged tissue.  These events include a dynamic interplay between cells with regenerative capacity and diverse inflammatory cells; bone marrow-derived cells are critical to these processes.  Current research efforts focus on the molecular and cellular mechanisms which regulate inflammation and the regeneration of murine skeletal muscle.

Selected Publications

Wang H, Melton DW, Porter L, Sarwar ZU, McManus LM, Shireman PK. Altered Macrophage Phenotype Transition Impairs Skeletal Muscle Regeneration. Am J Pathol. 2014 Feb 11.

Chen Y, Melton DW, Gelfond JA, McManus LM, Shireman PK. MiR-351 transiently increases during muscle regeneration and promotes progenitor cell proliferation and survival upon differentiation. Physiol Genomics. 2012 Nov 1;44(21):1042-51.

Lee LS, Pusek SN, McCormack WT, Helitzer DL, Martina CA, Dozier AM, Ahluwalia JS, Schwartz LS, McManus LM, Reynolds BD, Haynes EN, Rubio DM. Clinical and translational scientist career success: metrics for evaluation. Clin Transl Sci. 2012 Oct;5(5):400-7.

Burns SK, Dodd GD 3rd, McManus LM, Cardan RA, Peng Q, Orsi MD, Head HW, Blakemore DL, Blume JD, Fullerton GD, Green TJ. 3T magnetic resonance imaging accurately depicts radiofrequency ablation zones in a blood-perfused bovine liver model. J Vasc Interv Radiol. 2012 Jun;23(6):801-8.

McHale MJ, Sarwar ZU, Cardenas DP, Porter L, Salinas AS, Michalek JE, McManus LM, Shireman PK. Increased fat deposition in injured skeletal muscle is regulated by sex-specific hormones. Am J Physiol Regul Integr Comp Physiol. 2012 Feb 1;302(3):R331-9.


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The Sam and Ann Barshop Institute for Longevity and Aging Studies

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