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Barshop Institute for Longevity and Aging Studies

Kristine S. Vogel, Ph.D.

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Kristine S. Vogel, Ph.D.

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Assistant Professor
Department of Cell Systems and Anatomy
University of Texas Health Science Center at San Antonio
Phone: 210-567-0259

RESEARCH

Neurofibromatosis Type 1 (NF1) is a common genetic cancer syndrome that primarily affects derivatives of the neural crest, including Schwann cells and melanocytes; other tissues, such as bone and the CNS, are also involved in some patients. The expressivity, progression, and prognosis for NF1 can be highly variable, even among family members with the same germline mutation in the NF1 gene. Currently, my laboratory uses a mouse model for peripheral nerve sheath tumors (PNST), which I generated as a postdoctoral fellow in Dr. Luis Parada's laboratory, to examine the contributions of genomic instability to NF1 disease progression.

Selected Publications

Vogel KS, Perez M, Momand JR, Acevedo-Torres K, Hildreth K, Garcia RA, Torres-Ramos CA, Ayala-Torres S, Prihoda TJ, McMahan CA, Walter CA. Age-related instability in spermatogenic cell nuclear and mitochondrial DNA obtained from Apex1 heterozygous mice. Mol Reprod Dev. 2011 Dec;78(12):906-19.

Xu G, Vogel KS, McMahan CA, Herbert DC, Walter CA. BAX and tumor suppressor TRP53 are important in regulating mutagenesis in spermatogenic cells in mice. Biol Reprod. 2010 Dec;83(6):979-87.

Garza R, Hudson RA 3rd, McMahan CA, Walter CA, Vogel KS. A mild mutator phenotype arises in a mouse model for malignancies associated with neurofibromatosis type 1. Mutat Res. 2007 Feb 3;615(1-2):98-110.

Ling BC, Wu J, Miller SJ, Monk KR, Shamekh R, Rizvi TA, Decourten-Myers G, Vogel KS, DeClue JE, Ratner N. Role for the epidermal growth factor receptor in neurofibromatosis-related peripheral nerve tumorigenesis. Cancer Cell. 2005 Jan;7(1):65-75.

Miller SJ, Li H, Rizvi TA, Huang Y, Johansson G, Bowersock J, Sidani A, Vitullo J, Vogel K, Parysek LM, DeClue JE, Ratner N. Brain lipid binding protein in axon-Schwann cell interactions and peripheral nerve tumorigenesis. Mol Cell Biol. 2003 Mar;23(6):2213-24.


 
 
   
 
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The Sam and Ann Barshop Institute for Longevity and Aging Studies

15355 Lambda Drive
San Antonio, Texas  78245
P: 210-562-6140 F: 210-562-6110

Contact: barshopinstitute@uthscsa.edu
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