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Barshop Institute for Longevity and Aging Studies

Matthew J. Hart, Ph.D.


Matthew J. Hart, Ph.D.

Assistant Professor/Research
Department of Molecular Medicine
Barshop Institute for Longevity and Aging Studies
University of Texas Health Science Center at San Antonio
Phone: 210-562-6006


Dr. Hart has extensive knowledge of high-throughput screening through his experience of many steps in the drug discovery process, including assay development, optimization and automation. He has many years of experience running HTS in the biotechnology industry, having successfully lead screens using 500,000 compound libraries to identify kinase inhibitors, protease cleavage inhibitors, and others. In addition, Dr. Hart has a strong background in cancer signaling pathways, having made significant contributions to the field of GTPase regulation and beta-catenin biology.

Selected Publications

Qiang Zhang; Olivier Descamps; Matthew J. Hart; Karen S. Poksay; Patricia Spilman; Darci J. Kane; Olivia Gorostiza; Varghese John; Dale E. Bredesen Paradoxical effect of TrkA inhibition in alzheimer's disease models Journal of Alzheimer's Disease. 2014;40(3):605-617.

Anson Pierce; Natalia Podlutskaya; Jonathan J. Halloran; Stacy A. Hussong; Pei-Yi Lin; Raquel Burbank; Matthew J. Hart; Veronica Galvan Over-expression of heat shock factor 1 phenocopies the effect of chronic inhibition of TOR by rapamycin and is sufficient to ameliorate Alzheimer's-like deficits in mice modeling the disease Journal of Neurochemistry. 2013;124(6):880-893.

Veena Theendakara; Alexander Patent; Clare A. Peters Libeu; Brittany Philpot; Sonia Flores; Olivier Descamps; Karen S. Poksay; Qiang Zhang; Gabriellee Cailing; Matthew Hart; et al. Neuroprotective Sirtuin ratio reversed by ApoE4 Proceedings of the National Academy of Sciences of the United States of America. 2013;110(45):18303-18308.


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The Sam and Ann Barshop Institute for Longevity and Aging Studies

15355 Lambda Drive
San Antonio, Texas  78245
P: 210-562-6140 F: 210-562-6150

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