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Barshop Institute for Longevity and Aging Studies

Samy L. Habib, M.S., Ph.D.

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Samy L. Habib, M.S., Ph.D.

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Associate Professor, Research Scientist, South Texas Veterans Health System
Department of Cell Systems and Anatomy
University of Texas Health Science Center at San Antonio
South Texas Veterans Health System
Phone:210-567-3816

RESEARCH

The major emphasis of the work in my laboratory is on identifying the molecular mechanisms mediating fibrosis, hypertrophy and apoptosis in diabetic nephropathy, as well as defining the role of diabetes in the development of renal tumors. Novel finding from our lab confirmed that tuberin, a tumor suppressor protein, regulates the DNA repair enzyme OGG1 pathway. Dysregulation of this pathway leads to accumulation of oxidative DNA damage and predisposes tissue to cancer. Our studies are carried out in cultured cells, animal models, and in kidney tumors of patient with Tuberous Sclerosis Complex(TSC) disease.

Selected Publications

Samy L Habib Tuberin in renal cell hypertrophy. Cell Cycle. 2014;13:869.

M Nowacki ; Samy L Habib Is regenerative medicine a new hope for kidney replacement? J Artif Organs. 2014;17:123.

Sitai Liang; Samy L Habib Hyperactivation of Akt/mTOR and deficiency in tuberin increased the oxidative DNA damage in kidney cancer patients with diabetes. Oncotarget. 2014;5:2542.

 


 
 
   
 
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The Sam and Ann Barshop Institute for Longevity and Aging Studies

15355 Lambda Drive
San Antonio, Texas  78245
P: 210-562-6140 F: 210-562-6110

Contact: barshopinstitute@uthscsa.edu
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