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Barshop Institute for Longevity and Aging Studies

James P. Chambers, Ph.D.

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James P. Chambers, Ph.D.

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Professor of Biochemistry
Department of Biology
University of Texas at San Antonio
Phone: 210-458-5477

RESEARCH

Regulation of intracellular free calcium and its maintenance at extremely low concentrations (submicromolar) is one of the main tasks of cells. Transient calcium fluxes induce the activation of calcium-dependent second messenger systems. Thus, extrusion of excess calcium is critical to the well-being of the cell. Bulk amounts of calcium are removed from the cell cytosol by a Na+/Ca2+ exchanger. In contrast, removal of threshold amounts of free calcium is dependent upon a low capacity, high affinity plasma membrane calcium pump that couples Ca2+ translocation with ATP hydrolysis. We are interested in the characterization of calcium binding proteins in the cell and in particular the kinetic analysis of the [Ca2+ + MG 2+] - dependent adenosine-triphosphatase.

Selected Publications

Jupelli, M., Selby, D.M., Guentzel, M.N., Chambers, J.P., Forsthuber, T.G., Zhong, G., Murthy, A.K. and Arulanandam, B.P.The Contribution of Il-12/IFN-γ Axis in Protection Against Neonatal Pulmonary Chlamydia muridarum Challenge Journal of Interferon and Cytokine Research, 30(6): 407-415, 2010.

Yu, J.J., Goluguri, T.R., Guentzel, M.N., Forsthuber, T.G., Chambers, J.P., Murthy, A.K., Klose, K.E., and Arulanandam B.P.Francisella tularensis T Cell Antigen Identification Using Humanized HLA-DR4 Transgenic Mice Clinical & Vaccine Immunology, 17: 215-222, 2010.

Chaganty, B.K.R., Murthy, A.K., Evani, S.J., Li., W., Guentzel, M.N., Chambers, J.P., Zhong, G., Arulanandam, B.P.Heat Denatured Enzymatically Inactive Recombinant Chlamydial Protease-like Activity Factor Induces Robust Protective Immunity Against Genital Chlamydial ChallengeVaccine, 28: 2323-2329, 2010.


 
 
   
 
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The Sam and Ann Barshop Institute for Longevity and Aging Studies

15355 Lambda Drive
San Antonio, Texas  78245
P: 210-562-6140 F: 210-562-6110

Contact: barshopinstitute@uthscsa.edu
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