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Barshop Institute for Longevity and Aging Studies

Peter H. Dube, Ph.D.

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Peter H. Dube, Ph.D.

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Associate Professor
Department of Microbiology, Immunology, and Molecular Genetics
University of Texas Health Science Center at San Antonio
Phone: 210-562-4181

RESEARCH

The research in the Dube laboratory is focused on inflammation and how inflammation leads to disease. In particular, we investigate how bacterial pathogens and their products influence inflammatory responses. The three major areas of interest are pulmonary infections leading to asthma or the exacerbation of asthma, acute infections of the lungs by biodefense-related pathogens and infectious gastroenteritis caused by invasive bacterial pathogens. Our interests in asthma revolve around Mycoplasma pneumoniae and a toxin produced by this pathogen called the Community Acquired Respiratory Distress Syndrome toxin (CARDS toxin). Mycoplasma pneumoniae is often associated with acute exacerbations of asthma in children and adults and recent data suggests that CARDS toxin might be linked to a subset of asthma exacerbations. We are currently investigating how the CARDS toxin influences the immune system to promote asthma-like responses. Using a variety of animal models we have been able to show that exposure to purified CARDS toxin or low dose infection with M. pneumoiniae leads to the development of asthma-like inflammation in naive animals or exacerbation of asthma-like inflammation in animals with experimental asthma. We are using these models to dissect the immunological mechanisms responsible for generation of M. pneumoniae and CARDS toxin-associated asthma responses. 

Selected Publications

Evseev AI, Semenov I, Archer CR, Medina JL, Dube PH, Shapiro MS, Brenner R. Functional effects of KCNQ K(+) channels in airway smooth muscle. Front Physiol. 2013 Oct 7;4:277.

Bose R, Thinwa J, Chaparro P, Zhong Y, Bose S, Zhong G, Dube PH. Mitogen-activated protein kinase-dependent interleukin-1α intracrine signaling is modulated by YopP during Yersinia enterocolitica infection. Infect Immun. 2012 Jan;80(1):289-97.

Medina JL, Coalson JJ, Brooks EG, Winter VT, Chaparro A, Principe MF, Kannan TR, Baseman JB, Dube PH. Mycoplasma pneumoniae CARDS toxin induces pulmonary eosinophilic and lymphocytic inflammation. Am J Respir Cell Mol Biol. 2012 Jun;46(6):815-22.

Embry A, Meng X, Cantwell A, Dube PH, Xiang Y. Enhancement of immune response to an antigen delivered by vaccinia virus by displaying the antigen on the surface of intracellular mature virion. Vaccine. 2011 Jul 26;29(33):5331-9.

Cantwell AM, Bubeck SS, Dube PH. YopH inhibits early pro-inflammatory cytokine responses during plague pneumonia. BMC Immunol. 2010 Jun 16;11:29.


 
 
   
 
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The Sam and Ann Barshop Institute for Longevity and Aging Studies

15355 Lambda Drive
San Antonio, Texas  78245
P: 210-562-6140 F: 210-562-6110

Contact: barshopinstitute@uthscsa.edu
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