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Barshop Institute for Longevity and Aging Studies

Robert A. Marciniak, M.D., Ph.D.

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Robert A. Marciniak, M.D., Ph.D.

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Associate Professor
Department of Cell Systems and Anatomy
University of Texas Health Science Center at San Antonio
Phone: 210-567-4786

RESEARCH

Our research centers on the basic biology of aging and cancer, emphasizing the interrelationship between the two. Initially we have taken a genetic approach, and have focused on the analysis of a progeriod disorder, Werner syndrome. Werner syndrome is a human autosomal recessive disorder characterized by symptoms suggestive of premature aging and a predisposition to cancer. Our analysis of the molecular defect that causes Werner syndrome has led to the study of its involvement in telomere processing. We are currently investigating the role that the Werner syndrome helicase (WRN) may play in telomere maintenance and how the loss of the function of this protein and dysfunctional telomere processing - can lead to both symptoms of premature aging and increased cancer incidence.

Selected Publications

Siddiqa A, Cavazos D, Chavez J, Long L, Marciniak RA. Modulation of telomeres in alternative lengthening of telomeres type I like human cells by the expression of werner protein and telomerase. J Oncol. 2012;2012:806382.

Friedrichs W, Ruparel SB, Marciniak RA, deGraffenried L. Omega-3 fatty acid inhibition of prostate cancer progression to hormone independence is associated with suppression of mTOR signaling and androgen receptor expression. Nutr Cancer. 2011;63(5):771-7.

Siddiqa A, Long LM, Li L, Marciniak RA, Kazhdan I. Expression of HER-2 in MCF-7 breast cancer cells modulates anti-apoptotic proteins Survivin and Bcl-2 via the extracellular signal-related kinase (ERK) and phosphoinositide-3 kinase (PI3K) signalling pathways. BMC Cancer. 2008 May 2;8:129.

Siddiqa A, Marciniak R. Targeting the hallmarks of cancer. Cancer Biol Ther. 2008 May;7(5):740-1.

Silva J, Cavazos DA, Donzis E, Friedrichs WE, Marciniak R, deGraffenried LA. Akt-induced tamoxifen resistance is associated with altered FKHR regulation. Cancer Invest. 2007;25(7):569-73.


 
 
   
 
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The Sam and Ann Barshop Institute for Longevity and Aging Studies

15355 Lambda Drive
San Antonio, Texas  78245
P: 210-562-6140 F: 210-562-6110

Contact: barshopinstitute@uthscsa.edu
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