My Research Interests:
I seek to identify molecular mechanisms by which mitochondrial dysfunction regulates cellular senescence in aging and aging related diseases. This is an important project, since recent work from several labs demonstrated a key role of cellular senescence in aging and aging-related diseases, but the underlying connection is poorly identified. My project focuses on a novel metabolic pathway mediated by ALCAT1, the first acyltransferase that catalyzes the remodeling of cardiolipin. ALCAT1 links cellular senescence to the onset of aging and aging-related diseases through regulation of mitochondrial dysfunction. I employ molecular, cellular, mitochondrial approaches, as well as mouse models of targeted deletion of ALCAT1 for the studies.
Why I Pursued Aging Research:
Despite the significant evidence indicating that aging is a driving force for the development of aging-related metabolic diseases, including obesity, type II diabetes mellitus, and cardiovascular diseases, the molecular mechanisms underlying a causative role of these pathogenic conditions remains poorly understood.
My Future Plans:
Primary Investigator at a research institution or Scientist in research industry.
Awards and Honors:
- 2016 1st prize winner, San Antonio Annual Postdoctoral Research Forum. San Antonio Life Sciences Institute (SALSI), USA
- 2016 APS Select. Distinction in Scholarship, APS - Heart and Circulatory Physiology, USA
- 2015 Minority Travel Fellowship Award. American Physiological Society (APS), USA
- 2015 Minority Travel Grant. American Heart Association, Scientific sessions BCVS, USA
- 2012 Chancellor’s Fund. University of Northampton, UK
- 2011 1st prize winner. Annual graduate school poster competition, University of Northampton, UK
- 2009 T.D Lewis scholarship to study aging at the Buck Institute for Research on Aging (USA)
Mdaki KS, Zhang Jun, Shi Y. 2016. Acyl-CoA:lysocardiolipin acyltransferase regulate cellular bioenergetics and lysosomal function: implications for aging and age-related diseases. Pathobiology of Aging & Age-related Diseases. 2016 December; 6:34153.
Mdaki KS, et al. 2016. Maternal high-fat diet impairs cardiac function in offspring of diabetic pregnancy through metabolic stress and mitochondrial dysfunction. American journal of physiology. Heart and circulatory physiology. 2016; 310(6):H681-92.
Mdaki KS, Larsen TD, Weaver LJ, Baack ML. 2016. Age Related Bioenergetics Profiles in Isolated Rat Cardiomyocytes Using Extracellular Flux Analyses. PloS one. 2016; 11(2):e0149002.
Mdaki K. 2013. An investigation of the effects of aluminium on mitochondrial bioenergetics via aconitase inactivation : implications for development, ageing and chronic disease. (British Library, Doctoral Thesis).
Complete List of Published Work in My Bibliography: https://www.ncbi.nlm.nih.gov/sites/myncbi/1PM2zKnWhP8QM/bibliography/50567043/public/?sort=date&direction=descending